![]() CYP2B6 inducers: Dose increase may be necessary if coadministered with CYP2B6 inducers (e.g., ritonavir, lopinavir, efavirenz, carbamazepine, phenobarbital, and phenytoin) based on clinical exposure, but should not exceed the maximum recommended dose.Angle-Closure Glaucoma: Angle-closure glaucoma has occurred in patients with untreated anatomically narrow angles treated with antidepressants.Psychosis and Other Neuropsychiatric Reactions: Instruct patients to contact a healthcare professional if such reactions occur.Activation of Mania/Hypomania: Screen patients for bipolar disorder and monitor for these symptoms.Monitor blood pressure before initiating treatment and periodically during treatment. Hypertension: Wellbutrin XL can increase blood pressure.Can minimize risk by limiting daily dose to 450 mg and gradually increasing the dose. Seizure Risk: The risk is dose-related.Observe patients attempting to quit smoking with Wellbutrin XL for the occurrence of such symptoms and instruct them to discontinue Wellbutrin XL and contact a healthcare provider if they experience such adverse events. ![]() Neuropsychiatric Adverse Events During Smoking Cessation: Postmarketing reports of serious or clinically significant neuropsychiatric adverse events have included changes in mood (including depression and mania), psychosis, hallucinations, paranoia, delusions, homicidal ideation, aggression, hostility, agitation, anxiety, and panic, as well as suicidal ideation, suicide attempt, and completed suicide.
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